Modafinil in the body
Distribution: Vd: 0.9 L/kg
Protein binding: 60%, primarily to albumin
Metabolism: Hepatic; multiple pathways including CYP3A4
Half-life elimination: Effective half-life: 15 hours; Steady-state: 2-4 days
Time to peak, serum: 2-4 hours
Excretion: Urine (as metabolites, <10% as unchanged drug)
Can I take Modafinil if I’m on hormonal birth controls?
Yes, but Modafinil can affect birth control pills and how they work. Discuss this issue with your doctor.
Can I take Modafinil if I’m pregnant or nursing?
No, but ask your doctor.
Are there side effects?
Do they prescribe Modafinil to kids?
Modafinil has not been approved by the Food and Drug Administration for pediatric use.
It was thought that modafinil had a low additive potential, especially compared to other stimulants. A recent study has cast doubt on that view and found that modafinil affects the same dopamine system in the brain that other drugs affect. So it may be physically addictive. In any case, use the drug only if you need it and are under a doctor’s care.